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1

Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen–positive chronic hepatitis B

Patrick Marcellin, Ting-Tsung Chang, Seng G. Lee Lim, William Sievert, Myron Tong, Sarah Arterburn, Katyna Borroto-Esoda, David Frederick, Franck Rousseau

Journal:

Year:

2008

Language:

english

File:

PDF, 277 KB

english, 2008

2

Nucleoside Diphosphate Kinase and the Activation of Antiviral Phosphonate Analogs of Nucleotides: Binding Mode and Phosphorylation of Tenofovir Derivatives

Koch, Kerstin, Chen, Yuxing, Feng, Joy Y., Borroto-Esoda, Katyna, Deville-Bonne, Dominique, Janin, Joël, Moréra, Solange

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2009

Language:

english

File:

PDF, 2.88 MB

english, 2009

3

Effects of HIV Q151M-associated multi-drug resistance mutations on the activities of (−)-β-d-1′,3′-dioxolan guanine

Joy Y. Feng, Florence Myrick, Boulbaba Selmi, Jérôme Deval, Bruno Canard, Katyna Borroto-Esoda

Journal:

Antiviral Research

Year:

2005

Language:

english

File:

PDF, 109 KB

english, 2005

4

Mutations in the RNaseH Region Observed in the HIV-1 of Antiretroviral Treatment (ART) Experienced Patients

J. Waters, W. O’Neal, K. White, E. Lansdon, M. Miller, J. Harris, K. Borroto-Esoda

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 61 KB

english, 2007

5

The Triple Combination of Tenofovir, Emtricitabine and Efavirenz Shows Synergistic Anti-HIV-1 Activity In Vitro

F. Myrick, J. Feng, E. Svarovskaia, M. Miller, K. Borroto-Esoda

Journal:

Antiviral Research

Year:

2007

Language:

english

File:

PDF, 59 KB

english, 2007

6

Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5′-phosphates by mammalian phosphotransferases

Joy Y. Feng, William B. Parker, Megan L. Krajewski, Dominique Deville-Bonne, Michel Veron, Preethi Krishnan, Yung-Chi Cheng, Katyna Borroto-Esoda

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 172 KB

english, 2004

7

HBV DNA replication mediated by cloned patient HBV reverse transcriptase genes from HBV genotypes A–H and its use in antiviral phenotyping assays

Yuao Zhu, Maria Curtis, Katyna Borroto-Esoda

Journal:

Journal of Virological Methods

Year:

2011

Language:

english

File:

PDF, 518 KB

english, 2011

8

Preliminary efficacy, pharmacokinetics and safety of repeated multiple doses of MKC-442 in HIV-infected volunteers

CP Moxham, K Borroto-Esoda, D Noel, PA Furman, GM Szczech, DW Barry

Journal:

Antiviral Research

Year:

1997

Language:

english

File:

PDF, 30 KB

english, 1997

9

Therapy of chronic hepatitis B: trends and developments

William E Delaney IV, Katyna Borroto-Esoda

Journal:

Current Opinion in Pharmacology

Year:

2008

Language:

english

File:

PDF, 432 KB

english, 2008

10

Pooled analysis of amino acid changes in the HBV polymerase in patients from four major adefovir dipivoxil clinical trials

Katyna Borroto-Esoda, Michael D. Miller, Sarah Arterburn

Journal:

Journal of Hepatology

Year:

2007

Language:

english

File:

PDF, 199 KB

english, 2007

11

483 Final analysis of virological outcomes and resistance during 5 years of adefovir dipivoxil monotherapy in HBeAg-negative patients

K. Borroto-Esoda, S. Arterburn, A. Snow, S. Chuck, S. Hadziyannis, S. Locamini, E. Zoulim, J.-M. Pawlotsky

Journal:

Journal of Hepatology

Year:

2006

Language:

english

File:

PDF, 249 KB

english, 2006

12

494 Two-state modeling of virological and biochemical efficacy plus liver biopsies demonstrate efficacy of adefovir dipivoxil in HBeAg-negative chronic hepatitis B over four or five years

S. Hadziyannis, N. Tassopoulos, T.T. Chang, E.J. Heathcote, G. Kitis, M. Rizzetto, E. Marcellin, S.G. Lim, Z. Goodman, S. Arterbum, J. Ma, K. Borroto-Esoda, E. Mondou, S. Chuck

Journal:

Journal of Hepatology

Year:

2006

Language:

english

File:

PDF, 122 KB

english, 2006

13

[56] HBV RTI233V POLYMERASE VARIANT REMAINS SENSITIVE TO ADEFOVIR

M. Curtis, Y. Zhu, K. Borroto-Esoda

Journal:

Journal of Hepatology

Year:

2007

Language:

english

File:

PDF, 263 KB

english, 2007

14

76 TENOFOVIR DISOPROXIL FUMARATE (TDF) VERSUS EMTRICITABINE PLUS TDF FOR TREATMENT OF CHRONIC HEPATITIS B (CHB) IN SUBJECTS WITH PERSISTENT VIRAL REPLICATION RECEIVING ADEFOVIR DIPIVOXIL (ADV)

T. Berg, B. Moller, H. Trinh, S. Chan, P. Marcellin, E. Suarez, A. Snow-Lampart, D. Frederick, D. Oldach, J. Sorbel, K. Borroto-Esoda, F. Rousseau

Journal:

Journal of Hepatology

Year:

2008

Language:

english

File:

PDF, 59 KB

english, 2008

15

689 LACK OF INFLUENCE OF BASELINE GENOTYPE ON ANTIVIRAL RESPONSE IN SUBJECTS WITH CHRONIC HEPATITIS B INFECTION RECEIVING TENOFOVIR DF 300 MG QD FOR 1 YEAR

E. Gane, Y. Benhamou, A. Gladysz, S. Zeuzem, G. Germanidis, J. Heathcote, P. Marcellin, J. Sorbel, K. Borroto-Esoda, F. Rousseau, A. Snow-Lampart

Journal:

Journal of Hepatology

Year:

2008

Language:

english

File:

PDF, 66 KB

english, 2008

16

934 EVOLUTION OF VIRAL LOAD AND GENOME SEQUENCE IN A CLINICAL TRIAL OF TENOFOVIR/EMTRICITABINE COMBINATION VERSUS TENOFOVIR MONOTHERAPY FOR PATIENTS WITH PREVIOUS ADEFOVIR DIPIVOXIL FAILURE

F. Lavocat, C. Pichoud, P. Deny, K. Borroto-Esoda, J. Sorbel, F. Rousseau, D. Durantel, F. Zoulim

Journal:

Journal of Hepatology

Year:

2009

Language:

english

File:

PDF, 50 KB

english, 2009

17

903 TENOFOVIR DISOPROXIL FUMARATE (TDF) VERSUS EMTRICITABINE PLUS TDF (FTC/TDF) FOR TREATMENT OF CHRONIC HEPATITIS B (CHB) IN PATIENTS WITH PERSISTENT VIRAL REPLICATION RECEIVING ADEFOVIR DIPIVOXIL

T. Berg, B. Moller, H. Trinh, S. Chan, P. Marcellin, E. Suarez, A. Snow-Lampart, D. Oldach, J. Sorbel, K. Borroto-Esoda, D. Frederick, F. Rousseau

Journal:

Journal of Hepatology

Year:

2009

Language:

english

File:

PDF, 88 KB

english, 2009

18

P.102 Long-term adefovir dipivoxil treatment induces regression of liver fibrosis in patients with HBeAg-negative chronic hepatitis B: results after 5 years of therapy

S.J. Hadziyannis, N.C. Tassopoulos, T. Chang, J. Heathcote, G. Kitis, M. Rizzetto, P. Marcellin, S. Lim, Z. Goodman, S. Arterburn, J. Ma, K. Borroto-Esoda, E. Mondou, S.L. Chuck

Journal:

Journal of Clinical Virology

Year:

2006

Language:

english

File:

PDF, 138 KB

english, 2006

19

P.105 Final analysis of virological outcomes and resistance during 5 years of adefovir dipivoxil monotherapy in hepatitis B e antigen-negative patients

K. Borroto-Esoda, S. Arterburn, A. Snow, S. Chuck, S. Hadziyannis, S. Locarnini, J. Pawlotsky, F. Zoulim

Journal:

Journal of Clinical Virology

Year:

2006

Language:

english

File:

PDF, 134 KB

english, 2006

20

Development of a human immunodeficiency virus-1 in vitro DNA synthesis system to study reverse transcriptase inhibitors

Katyna Borroto-Esoda, Lawrence R. Boone

Journal:

Antiviral Research

Year:

1994

Language:

english

File:

PDF, 1.21 MB

english, 1994

21

Hepatitis B virus wild-type and rtN236T populations show similar early HBV DNA decline in adefovir refractory patients on a tenofovir-based regimen

E. S. Svarovskaia, M. Curtis, Y. Zhu, K. Borroto-Esoda, M. D. Miller, T. Berg, F. Lavocat, F. Zoulim, K. M. Kitrinos

Journal:

Journal of Viral Hepatitis

Year:

2012

Language:

english

File:

PDF, 283 KB

english, 2012

22

The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activityin vitro: a mechanism of action study

Joy Y Feng, John K Ly, Florence Myrick, Derrick Goodman, Kirsten L White, Evguenia S Svarovskaia, Katyna Borroto-Esoda, Michael D Miller

Journal:

Year:

2009

Language:

english

File:

PDF, 1.23 MB

english, 2009

23

322 Tenofovir Disoproxil Fumarate (TDF) Versus Emtricitabine Plus TDF (FTC/TDF) for Treatment of Chronic Hepatitis B (CHB) in Patients with Persistent Viral Replication Receiving Adefovir Dipivoxil

Berg, Thomas, Moeller, Bernd, Trinh, Huy N., Chan, Sing, Marcellin, Patrick, Suarez, Emilio, Snow-Lampart, Andrea, Oldach, David W., Sorbel, Jeff, Borroto-Esoda, Katyna, Frederick, David, Rousseau, Fr

Journal:

Gastroenterology

Year:

2009

Language:

english

File:

PDF, 74 KB

english, 2009

24

Hypoxemia is a possible factor in chronicization of nAnB hepatitis in cardiosurgical patients

Berg, Thomas, Moeller, Bernd, Trinh, Huy N., Chan, Sing, Marcellin, Patrick, Suarez, Emilio, Snow-Lampart, Andrea, Oldach, David W., Sorbel, Jeff, Borroto-Esoda, Katyna, Frederick, David, Rousseau, Fr

Journal:

Journal of Hepatology

Year:

1986

Language:

english

File:

PDF, 69 KB

english, 1986

25

Cyclophilin Inhibitors Reduce Phosphorylation of RNA-Dependent Protein Kinase to Restore Expression of IFN-Stimulated Genes in HCV-Infected Cells

Daito, Takuji, Watashi, Koichi, Sluder, Ann, Ohashi, Hirofumi, Nakajima, Syo, Borroto-Esoda, Katyna, Fujita, Takashi, Wakita, Takaji

Journal:

Gastroenterology

Year:

2014

Language:

english

File:

PDF, 2.50 MB

english, 2014

26

M1913 Lack of Influence of Baseline Genotype On Antiviral Response in Subjects with Chronic Hepatitis B Infection Receiving Tenofovir Df 300 Mg Qd for 1 Year

Younossi, Zobair M., Benhamou, Yves, Gane, Ed J., Zeuzem, Stefan, Heathcote, Jenny, Marcellin, Patrick, Sorbel, Jeff, Borroto-Esoda, Katyna, Rousseau, Franck, Snow-Lampart, Andrea

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 129 KB

english, 2008

27

10 CYCLOPHILIN INHIBITORS POTENTIATE INTERFERON SIGNALING THROUGH DIMINISHED PKR PHOSPHORYLATION IN HCV-INFECTED CELLS

Watashi, K., Daito, T., Sluder, A., Borroto-Esoda, K., Wakita, T.

Journal:

Journal of Hepatology

Year:

2013

Language:

english

File:

PDF, 60 KB

english, 2013

28

1170 THE CYCLOPHILIN INHIBITOR SCY-635 RESTORES THE INNATE RECOGNITION OF HCV BY PERIPHERAL BLOOD MONONUCLEAR CELLS (PBMC) FROM HCV POSITIVE SUBJECTS

Probst, P., Mosier, S., Scorneaux, B., Sluder, A., Heuman, D., Borroto-Esoda, K.

Journal:

Journal of Hepatology

Year:

2013

Language:

english

File:

PDF, 60 KB

english, 2013

29

1022 EVALUATION OF POTENTIAL VIROLOGIC RESISTANCE IN HBV POLYMERASE AMONG SUBJECTS WITH PERSISTENT VIREMIA FOLLOWING UP TO 144 WEEKS OF THERAPY WITH TENOFOVIR DF

Snow-Lampart, A., Chappell, B., Sorbel, J., Borroto-Esoda, K., Miller, M.

Journal:

Journal of Hepatology

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

30

Similar evolution of hepatitis B virus quasispecies in patients with incomplete adefovir response receiving tenofovir/emtricitabine combination or tenofovir monotherapy

Lavocat, Fabien, Dény, Paul, Pichoud, Christian, Al Hawajri, Nasser, Kitrinos, Kathryn, Borroto-Esoda, Katyna, Zoulim, Fabien

Journal:

Journal of Hepatology

Year:

2013

Language:

english

File:

PDF, 1.81 MB

english, 2013

31

1017 EFFICACY OF TENOFOVIR DF TREATMENT IN PATIENTS WITH A SUBOPTIMAL RESPONSE TO ADEFOVIR DIPIVOXIL

Manns, M., Heathcote, J., Marcellin, P., Berg, T., Anderson, J., Sorbel, J., Frederick, D., Rousseau, F., Borroto-Esoda, K.

Journal:

Journal of Hepatology

Year:

2010

Language:

english

File:

PDF, 51 KB

english, 2010

32

M1923 Tenofovir Disoproxil Fumarate (TDF) Versus Emtricitabine Plus TDF for Treatment of Chronic Hepatitis B (CHB) in Subjects with Persistent Viral Replication Receiving Adefovir Dipivoxil (ADV)

Berg, Thomas, Moeller, Bernd, Trinh, Huy N., Chan, Sing, Marcellin, Patrick, Suarez, Emilio, Snow-Lampart, Andrea, Frederick, David, Borroto-Esoda, Katyna, Oldach, David W., Sorbel, Jeff, Rousseau, Fr

Journal:

Gastroenterology

Year:

2008

Language:

english

File:

PDF, 71 KB

english, 2008

33

Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)

Watashi, Koichi, Sluder, Ann, Daito, Takuji, Matsunaga, Satoko, Ryo, Akihide, Nagamori, Shushi, Iwamoto, Masashi, Nakajima, Syo, Tsukuda, Senko, Borroto-Esoda, Katyna, Sugiyama, Masaya, Tanaka, Yasuhi

Journal:

Year:

2014

Language:

english

File:

PDF, 1.03 MB

english, 2014

34

No detectable resistance to tenofovir disoproxil fumarate after 6 years of therapy in patients with chronic hepatitis B

Kitrinos, Kathryn M., Corsa, Amoreena, Liu, Yang, Flaherty, John, Snow-Lampart, Andrea, Marcellin, Patrick, Borroto-Esoda, Katyna, Miller, Michael D.

Journal:

Year:

2014

Language:

english

File:

PDF, 618 KB

english, 2014

35

Virologic and Enzymatic Studies Revealing the Mechanism of K65R- and Q151M-Associated HIV-1 Drug Resistance Towards Emtricitabine and Lamivudine

Feng, Joy Y., Myrick, Florence T., Margot, Nicolas A., Mulamba, Gilbert B., Rimsky, Laurence, Borroto-Esoda, Katyna, Selmi, Boulbaba, Canard, Bruno

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2006

Language:

english

File:

PDF, 336 KB

english, 2006

36

Baseline Genotype as a Predictor of Virological Failure to Emtricitabine or Stavudine in Combination with Didanosine and Efavirenz

Borroto-Esoda, Katyna, Waters, Joshua M., Bae, Andrew S., Harris, Jeanette L., Hinkle, John E., Quinn, Joseph B., Rousseau, Frank S.

Journal:

AIDS Research and Human Retroviruses

Year:

2007

Language:

english

File:

PDF, 167 KB

english, 2007

37

The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase.

Wilson, J E, Martin, J L, Borroto-Esoda, K, Hopkins, S, Painter, G, Liotta, D C, Furman, P A

Journal:

Antimicrobial Agents and Chemotherapy

Year:

1993

Language:

english

File:

PDF, 856 KB

english, 1993

38

In Vitro Combination of Amdoxovir and the Inosine Monophosphate Dehydrogenase Inhibitors Mycophenolic Acid and Ribavirin Demonstrates Potent Activity against Wild-Type and Drug-Resistant Variants of Human Immunodeficiency Virus Type 1

Borroto-Esoda, K., Myrick, F., Feng, J., Jeffrey, J., Furman, P.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2004

Language:

english

File:

PDF, 394 KB

english, 2004

39

Molecular Mechanism of DAPD/DXG against Zidovudine- and Lamivudine- Drug Resistant Mutants: A Molecular Modelling Approach

Chong, Y., Borroto-Esoda, K., Furman, P. A., Schinazi, R. F., Chu, C. K.

Journal:

Antiviral Chemistry & Chemotherapy

Year:

2002

Language:

english

File:

PDF, 310 KB

english, 2002

40

Safety Assessment, In Vitro and In Vivo, and Pharmacokinetics of Emivirine, a Potent and Selective Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1

Szczech, G. M., Furman, P., Painter, G. R., Barry, D. W., Borroto-Esoda, K., Grizzle, T. B., Blum, M. R., Sommadossi, J.-P., Endoh, R., Niwa, T., Yamamoto, M., Moxham, C.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2000

Language:

english

File:

PDF, 105 KB

english, 2000

41

Anti-Hepatitis B Virus Activity in Vitro of Combinations of Tenofovir with Nucleoside/nucleotide Analogues

Zhu, Y., Curtis, M., Qi, X., Miller, M. D., Borroto-Esoda, K.

Journal:

Antiviral Chemistry & Chemotherapy

Year:

2009

Language:

english

File:

PDF, 886 KB

english, 2009

42

Mechanism of Action of 1- -D-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1- -D-Dioxolane Guanosine

Furman, P. A., Jeffrey, J., Kiefer, L. L., Feng, J. Y., Anderson, K. S., Borroto-Esoda, K., Hill, E., Copeland, W. C., Chu, C. K., Sommadossi, J.-P., Liberman, I., Schinazi, R. F., Painter, G. R.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2001

Language:

english

File:

PDF, 122 KB

english, 2001

43

A Comparison of the Phenotypic Susceptibility Profiles of Emtricitabine and Lamivudine

Borroto-Esoda, K., Parkin, N., Miller, M. D.

Journal:

Antiviral Chemistry & Chemotherapy

Year:

2007

Language:

english

File:

PDF, 126 KB

english, 2007

44

Low-Level Persistence of Drug Resistance Mutations in Hepatitis B Virus-Infected Subjects with a Past History of Lamivudine Treatment

Margeridon-Thermet, S., Svarovskaia, E. S., Babrzadeh, F., Martin, R., Liu, T. F., Pacold, M., Reuman, E. C., Holmes, S. P., Borroto-Esoda, K., Shafer, R. W.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 226 KB

english, 2013

45

MultiCode-RTx Real-Time PCR System for Detection of Subpopulations of K65R Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant Viruses in Clinical Samples

Svarovskaia, E. S., Moser, M. J., Bae, A. S., Prudent, J. R., Miller, M. D., Borroto-Esoda, K.

Journal:

Journal of Clinical Microbiology

Year:

2006

Language:

english

File:

PDF, 219 KB

english, 2006

46

The YMDD and rtA194T Mutations Result in Decreased Replication Capacity in Wild- Type HBV as well as in HBV with Precore and Basal Core Promoter Mutations

Zhu, Yuao, Curtis, Maria, Borroto-Esoda, Katyna

Journal:

Antiviral Chemistry & Chemotherapy

Year:

2011

Language:

english

File:

PDF, 500 KB

english, 2011

47

In Vitro Drug Susceptibility Analysis of Hepatitis B Virus Clinical Quasispecies Populations

Zhu, Y., Curtis, M., Snow-Lampart, A., Yang, H., Delaney, W., Miller, M. D., Borroto-Esoda, K.

Journal:

Journal of Clinical Microbiology

Year:

2007

Language:

english

File:

PDF, 275 KB

english, 2007

48

The A62V and S68G Mutations in HIV-1 Reverse Transcriptase Partially Restore the Replication Defect Associated With the K65R Mutation

Svarovskaia, Evguenia S, Feng, Joy Y, Margot, Nicolas A, Myrick, Florence, Goodman, Derrick, Ly, John K, White, Kirsten L, Kutty, Nilima, Wang, Ruth, Borroto-Esoda, Katyna, Miller, Michael D

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2008

Language:

english

File:

PDF, 211 KB

english, 2008

49

Reduced Emergence of the M184V/I Resistance Mutation When Antiretroviral-Naïve Subjects Use Emtricitabine Versus Lamivudine in Regimens Composed of Two NRTIs Plus the NNRTI Efavirenz

McColl, Damian J., Margot, Nicolas, Chen, Shan-Shan, Harris, Jeanette, Borroto-Esoda, Katyna, Miller, Michael D.

Journal:

HIV Clinical Trials

Year:

2011

Language:

english

File:

PDF, 254 KB

english, 2011

50

Dioxolane Guanosine, the Active Form of the Prodrug Diaminopurine Dioxolane, Is a Potent Inhibitor of Drug-Resistant HIV-1 Isolates From Patients for Whom Standard Nucleoside Therapy Fails

Mewshaw, Jennifer P., Myrick, Florence T., Wakefield, Debby A. C. S., Hooper, Brandi J., Harris, Jeanette L., McCreedy, Bruce, Borroto-Esoda, Katyna

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2002

File:

PDF, 6.81 MB

2002

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